The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Dvorak SN, Kurniali PC

BCNU (Bis-chloroethylnitrosourea, Carmustine) Toxicity Presented as a Large Pleural Effusion 60 Days Post Autologous Stem Cell Transplant for Non-Hodgkin Lymphoma.

Cureus 2019 Feb 12;11;e4052 — 2019 Feb 12 — e4052

Krishnan GS, Chaudhary V, Al-Janadi A, Ramanarayanan J, D'Silva KJ

BCNU toxicity presenting with a large pericardial and pleural effusion.

Annals of transplantation 2008;13;44-7 — 2008 — 44-7