The Drug-Induced Respiratory Disease Website and App

Breast implants - Augmentation mammaplasty (w/wo evidence for leakage/rupture)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.u

Vasculitis, pulmonary (w/wo AH), extrapulmonary, systemic: ANCA-positive

Publications

Tan J, Spath F, Malhotra R, Hamadeh Z, Acharya A

Microscopic Polyangiitis following Silicone Exposure from Breast Implantation.

Case reports in nephrology 2014;2014;902089 — 2014 — 902089

Bohgaki M, Mukai M, Notoya A, Kohno M, Takada A

Vasculitis following implantation of a ventriculoperitoneal shunt tube made of silicone.

Modern rheumatology 2003 Mar;13;73-5 — 2003 Mar — 73-5

Iyoda M, Ito J, Nagai H, Sato K, Kuroki A, Shibata T, Kitazawa K, Sugisaki T

Microscopic polyangiitis after silicone breast implantation.

Clinical and experimental nephrology 2005 Sep;9;252-4 — 2005 Sep — 252-4