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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Arora A, Inaty H, Mukhopadhyay S, Abu-Hijleh M, Mehta AC

Chronic Pulmonary Silicone Embolism Related to Saline Breast Implants.

Annals of the American Thoracic Society. 2016;13(1):139-41

Bois MC, Hu X, Roden AC, Yi ES, Ryu JH, Alexander MP

Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer.

Chest. 2014;146(6):e208-e211

Gopinath PP, Ali A, Van Tornout F, Kamath A, Crawford M, Nicholson AG

Chronic silicone embolism syndrome due to PIP breast implant leakage – a new entity?

Histopathology. 2015;66(6):904-6

Pineda JC, Díaz JC, Agualimpia A, García JF

Autoimmune/inflammatory syndrome induced by adjuvants causing myositis and pulmonary fibrosis.

The Israel Medical Association journal : IMAJ. 2013;15(11):720-1

Paredes Vila S, Gonzalez Barcala FJ, Suarez Antelo J, Moldes Rodriguez M, Abdulkader Nallib I, Valdes Cuadrado L

Pneumonitis caused by silicone gel following breast implant rupture.

Irish journal of medical science. 2010;179(1):141-5

Miyata Y, Okano R, Kuratomi Y

[Interstitial pneumonia associated with human adjuvant disease which developed 30 years after silicone augmentation mammoplasty].

Nihon Kyobu Shikkan Gakkai zasshi. 1997;35(10):1093-8