The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Blumenthal KG, Peter JG, Trubiano JA, Phillips EJ

Antibiotic allergy.

Lancet (London, England). 2019;393(10167):183-198

Khan NU, Shakeel N, Makda A, Mallick AS, Ali Memon M, Hashmi SH, Khan UR, Razzak JA

Anaphylaxis: incidence, presentation, causes and outcome in patients in a tertiary-care hospital in Karachi, Pakistan.

QJM : monthly journal of the Association of Physicians. 2013;106(12):1095-101

Brown SG, Stone SF, Fatovich DM, Burrows SA, Holdgate A, Celenza A, Coulson A, Hartnett L, Nagree Y, Cotterell C, Isbister GK

Anaphylaxis: clinical patterns, mediator release, and severity.

The Journal of allergy and clinical immunology. 2013;132(5):1141-1149.e5

Renaudin JM, Beaudouin E, Ponvert C, Demoly P, Moneret-Vautrin DA

Severe drug-induced anaphylaxis: analysis of 333 cases recorded by the Allergy Vigilance Network from 2002 to 2010.

Allergy. 2013;68(7):929-37

Solé D, Ivancevich JC, Borges MS, Coelho MA, Rosário NA, Ardusso L, Bernd LA, Latin American Anaphylaxis Working Group

Anaphylaxis in Latin American children and adolescents: the Online Latin American Survey on Anaphylaxis (OLASA).

Allergologia et immunopathologia. 2012;40(6):331-5

Shen Y, Li L, Grant J, Rubio A, Zhao Z, Zhang X, Zhou L, Fowler D

Anaphylactic deaths in Maryland (United States) and Shanghai (China): a review of forensic autopsy cases from 2004 to 2006.

Forensic science international. 2009;186(1-3):1-5

Low I, Stables S

Anaphylactic deaths in Auckland, New Zealand: a review of coronial autopsies from 1985 to 2005.

Pathology. 2006;38(4):328-32

Wang DY, Forslund C, Persson U, Wiholm BE

Drug-attributed anaphylaxis.

Pharmacoepidemiology and drug safety. 1998;7(4):269-74

Mullins RJ

Anaphylaxis: risk factors for recurrence.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2003;33(8):1033-40

Ford SA, Kam PC, Baldo BA, Fisher MM

Anaphylactic or anaphylactoid reactions in patients undergoing cardiac surgery.

Journal of cardiothoracic and vascular anesthesia. 2001;15(6):684-8

Pumphrey RS, Davis S

Under-reporting of antibiotic anaphylaxis may put patients at risk.

Lancet (London, England). 1999;353(9159):1157-8