The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XIX.f

BAL: Foamy macrophages

Macrophages and resident cells classically appear foamy, indicating excess undegraded membrane phospholipids, as a consequence of exposure to the lysosomotropic drug amiodarone

Publications

LeVee A, Trieu M, Bhattacharyya S, Sandhu G

Eosinophilic pneumonia: A rare manifestation of amiodarone toxicity diagnosed using traditional bronchoscopy.

Respiratory medicine case reports. 2019;27:100856

Sharma S, Patti R, Soni P, Ehrlich S, Kupfer Y

Amiodarone toxicity and the acute respiratory distress syndrome.

QJM : monthly journal of the Association of Physicians. 2019;112(11):880-881

Lee W, Ryu DR, Han SS, Ryu SW, Cho BR, Kwon H, Kim BR

Very early onset of amiodarone-induced pulmonary toxicity.

Korean circulation journal. 2013;43(10):699-701

Oh E, Siddiqui N, Worringer E, Schroeder K, Markowiak S, Alrehaili M, Safi F, Hinch BT, Assaly R

Acute amiodarone-induced lung toxicity.

The American journal of the medical sciences. 2015;349(1):89

Sato N, Kojima K, Horio Y, Goto E, Masunaga A, Ichiyasu H, Kohrogi H

Successful treatment of severe amiodarone pulmonary toxicity with polymyxin B-immobilized fiber column direct hemoperfusion.

Chest. 2013;143(4):1146-1150

Omeroglu G, Kalugina Y, Ersahin C, Wojcik EM

Amiodarone lung toxicity in a cardiac transplant candidate initially diagnosed by fine-needle aspiration: cytologic, histologic, and electronmicroscopic findings.

Diagnostic cytopathology. 2006;34(5):351-4

Stein B, Zaatari GS, Pine JR

Amiodarone pulmonary toxicity. Clinical, cytologic and ultrastructural findings.

Acta cytologica. 1987;31(3):357-61

Coudert B, Bailly F, Lombard JN, Andre F, Camus P

Amiodarone pneumonitis. Bronchoalveolar lavage findings in 15 patients and review of the literature.

Chest. 1992;102(4):1005-12