The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Schwaiblmair M, Berghaus T, Haeckel T, Wagner T, von Scheidt W

Amiodarone-induced pulmonary toxicity: an under-recognized and severe adverse effect?

Clinical research in cardiology : official journal of the German Cardiac Society. 2010;99(11):693-700

Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED

Amiodarone: review of pulmonary effects and toxicity.

Drug safety. 2010;33(7):539-58

Ghezel-Ahmadi V, Kürschner VC, Fisseler-Eckhoff A, Schirren J, Schmitz JE, Obenhaus T

[Amiodarone-induced pneumonitis. Lethal complication in a patient after thoracic surgery].

Der Anaesthesist. 2008;57(10):982-7

Dezile G, Roullier A, Arbeille-Brassart B

[Interstitial pneumopathy in subjects treated with amiodarone].

Presse medicale (Paris, France : 1983). 1983;12(43):2747-50

Esinger W, Schleiffer T, Leinberger H, Hertrich F, Köhler G, Gröger C, Raute-Kreinsen U

[Steroid-refractory amiodarone-induced pulmonary fibrosis. Clinical features and morphology after an amiodarone-free interval of 3 months].

Deutsche medizinische Wochenschrift (1946). 1988;113(42):1638-41