The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LV.s

Imaging: An area or areas of involvement with high attenuation numbers or metallic density

Publications

Hochhegger B, Soares Souza A, Zanetti G, Marchiori E

An enlarged heart with hyperdense consolidation.

The Netherlands journal of medicine 2013 Jul-Aug;71;317, 321 — 2013 Jul-Aug — 317, 321

Poll LW, May P, Koch JA, Hetzel G, Heering P, Mödder U

HRCT findings of amiodarone pulmonary toxicity: clinical and radiologic regression.

Journal of cardiovascular pharmacology and therapeutics 2001 Jul;6;307-11 — 2001 Jul — 307-11

Swensen SJ

Focal lung disease: CT and high-resolution CT applications.

Radiographics : a review publication of the Radiological Society of North America, Inc 1994 Jan;14;169-81; quiz 183-4 — 1994 Jan — 169-81; quiz 183-4

Kuhlman JE, Scatarige JC, Fishman EK, Zerhouni EA, Siegelman SS

CT demonstration of high attenuation pleural-parenchymal lesions due to amiodarone therapy.

Journal of computer assisted tomography 1987 Jan-Feb;11;160-2 — 1987 Jan-Feb — 160-2

Nicholson AA, Hayward C

The value of computed tomography in the diagnosis of amiodarone-induced pulmonary toxicity.

Clinical radiology 1989 Nov;40;564-7 — 1989 Nov — 564-7