The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.l

Postoperative ARDS

The role of higher than necessary FIO2 is suggested. Good practice is to adjust FIO2 to maintain SaO2 >90%

Publications

Baumann H, Fichtenkamm P, Schneider T, Biscoping J, Henrich M

Rapid onset of amiodarone induced pulmonary toxicity after lung lobe resection - A case report and review of recent literature.

Annals of medicine and surgery (2012). 2017;21:53-57

Fadahunsi O, Krol R

Acute amiodarone pulmonary toxicity following lung resection.

International journal of biomedical science : IJBS. 2014;10(3):217-20

Viswam D, Nair SG, Patel V, Nagaraj

Ultra-short course of low-dose amiodarone-induced post-operative fatal pulmonary toxicity.

The Journal of the Association of Physicians of India. 2011;59:443-7

Skroubis G, Galiatsou E, Metafratzi Z, Karahaliou A, Kitsakos A, Nakos G

Amiodarone-induced acute lung toxicity in an ICU setting.

Acta anaesthesiologica Scandinavica. 2005;49(4):569-71

Van Mieghem W, Coolen L, Malysse I, Lacquet LM, Deneffe GJ, Demedts MG

Amiodarone and the development of ARDS after lung surgery.

Chest. 1994;105(6):1642-5

Mickleborough LL, Maruyama H, Mohamed S, Rappaport DC, Downar E, Butany J, Sun Z

Are patients receiving amiodarone at increased risk for cardiac operations?

The Annals of thoracic surgery. 1994;58(3):622-9

Hawthorne HR, Wood MA, Stambler BS, Damiano RJ, Ellenbogen KA

Can amiodarone pulmonary toxicity be predicted in patients undergoing implantable cardioverter defibrillator implantation?

Pacing and clinical electrophysiology : PACE. 1993;16(12):2241-9

Nalos PC, Kass RM, Gang ES, Fishbein MC, Mandel WJ, Peter T

Life-threatening postoperative pulmonary complications in patients with previous amiodarone pulmonary toxicity undergoing cardiothoracic operations.

The Journal of thoracic and cardiovascular surgery. 1987;93(6):904-12