The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Kim YJ, Kim WS, Choi YH, Cheon JE, Choi JY, Kang HJ, Park JE, Ryu YJ, Kim IO

Radiologic evaluation of pulmonary injury following carmustine- and cyclophosphamide-based preparative regimen for autologous peripheral blood stem cell transplantation in children.

Pediatric radiology 2018 12;48;1875-1883 — 2018 12 — 1875-1883

Krishnan GS, Chaudhary V, Al-Janadi A, Ramanarayanan J, D'Silva KJ

BCNU toxicity presenting with a large pericardial and pleural effusion.

Annals of transplantation 2008;13;44-7 — 2008 — 44-7

Alessandrino EP, Bernasconi P, Colombo A, Caldera D, Martinelli G, Vitulo P, Malcovati L, Nascimbene C, Varettoni M, Volpini E, Klersy C, Bernasconi C

Pulmonary toxicity following carmustine-based preparative regimens and autologous peripheral blood progenitor cell transplantation in hematological malignancies.

Bone marrow transplantation 2000 Feb;25;309-13 — 2000 Feb — 309-13

Chap L, Shpiner R, Levine M, Norton L, Lill M, Glaspy J

Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment.

Bone marrow transplantation 1997 Dec;20;1063-7 — 1997 Dec — 1063-7

Weiss RB, Poster DS, Penta JS

The nitrosoureas and pulmonary toxicity.

Cancer treatment reviews 1981 Jun;8;111-25 — 1981 Jun — 111-25

Litam JP, Dail DH, Spitzer G, Vellekoop L, Verma DS, Zander AR, Dicke KA

Early pulmonary toxicity after administration of high-dose BCNU.

Cancer treatment reports 1981 Jan-Feb;65;39-44 — 1981 Jan-Feb — 39-44