The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.a

Pleural effusion (uni- or bilateral) (can accompany DI-LDs)

Publications

Hawatmeh A, Thawabi M, Jmeian A, Shaaban H, Shamoon F

Amiodarone-induced loculated pleural effusion without pulmonary parenchymal involvement: A case report and literature review.

Journal of natural science, biology, and medicine. 2017;8(1):130-133

Yaşar Bilge NS, Gönüllü E, Kaşifoğlu T, Korkmaz C

Amiodarone-induced pleural fluid is not always accompanied by a risk factor.

Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology. 2012;12(3):281-2

Uong V, Nugent K, Alalawi R, Raj R

Amiodarone-induced loculated pleural effusion: case report and review of the literature.

Pharmacotherapy. 2010;30(2):218

Gonzalez-Rothi RJ, Hannan SE, Hood CI, Franzini DA

Amiodarone pulmonary toxicity presenting as bilateral exudative pleural effusions.

Chest. 1987;92(1):179-82