The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.v

Relapsing or migrating pneumonitis/pneumonia (see also Id)

May occur as a manifestation of amiodarone-associated BOOP, if corticosteroids are tapered 'too early' (even after some months of steroid treatment) as a manifestation of extended storage of amiodarone in the tissue

Publications

Joelson J, Kluger J, Cole S, Conway M

Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.

Chest 1984 Feb;85;284-6 — 1984 Feb — 284-6

Scardi S, Ciani F, Pandullo C, Padrini R, Pivotti F

[Recurrent alveolitis caused by amiodarone].

Giornale italiano di cardiologia 1986 Feb;16;177-80 — 1986 Feb — 177-80

Camus P, Lombard JN, Perrichon M, Piard F, Guérin JC, Thivolet FB, Jeannin L

Bronchiolitis obliterans organising pneumonia in patients taking acebutolol or amiodarone.

Thorax 1989 Sep;44;711-5 — 1989 Sep — 711-5