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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.bn

Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes

Publications

Banerdt J, Johnson J, Sandler K, Maldonado F, Aboudara M

Silicone Lymphadenopathy after Rupture of Breast Implant.

American journal of respiratory and critical care medicine. 2020;201(11):e77-e78

Arora A, Inaty H, Mukhopadhyay S, Abu-Hijleh M, Mehta AC

Chronic Pulmonary Silicone Embolism Related to Saline Breast Implants.

Annals of the American Thoracic Society. 2016;13(1):139-41

Bois MC, Hu X, Roden AC, Yi ES, Ryu JH, Alexander MP

Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer.

Chest. 2014;146(6):e208-e211

Paredes Vila S, Gonzalez Barcala FJ, Suarez Antelo J, Moldes Rodriguez M, Abdulkader Nallib I, Valdes Cuadrado L

Pneumonitis caused by silicone gel following breast implant rupture.

Irish journal of medical science. 2010;179(1):141-5

Levine RL, Allen TC, Cartwright J Jr, Cagle PT

Silicone thorax due to a ruptured breast implant.

Chest. 2005;127(5):1854-7

Kazachkov EL, Fridman AB, Friss SA

[Granulomatous pleurisy after mammaplasty, induced by polyacrylamide gel].

Arkhiv patologii. 1998;60(3):58-61