The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Silicone droplets/vacuoles in lung tissue, pulmonary vasculature, or lymph nodes
Publications
Silicone Lymphadenopathy Following Rupture of Breast Implant.
American journal of respiratory and critical care medicine 2020 Jan 09;; — 2020 Jan 09
Chronic Pulmonary Silicone Embolism Related to Saline Breast Implants.
Annals of the American Thoracic Society 2016 Jan;13;139-41 — 2016 Jan — 139-41
Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer.
Chest 2014 Dec;146;e208-e211 — 2014 Dec — e208-e211
Paredes Vila S, Gonzalez Barcala FJ, Suarez Antelo J, Moldes Rodriguez M, Abdulkader Nallib I, Valdes Cuadrado L
Pneumonitis caused by silicone gel following breast implant rupture.
Irish journal of medical science 2010 Mar;179;141-5 — 2010 Mar — 141-5
Silicone thorax due to a ruptured breast implant.
Chest 2005 May;127;1854-7 — 2005 May — 1854-7
[Granulomatous pleurisy after mammaplasty, induced by polyacrylamide gel].
Arkhiv patologii 1998 May-Jun;60;58-61 — 1998 May-Jun — 58-61