The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.f

Bluish, pseudocyanotic skin discoloration

Publications

Petreski T, Piko N, Privšek M, Zorman T, Bevc S

Blue Woman Syndrome and Thyrotoxicosis in a Patient on Amiodarone.

European journal of case reports in internal medicine. 2020;7(4):001526

Fishman TJ, Spencer S, Harrell R, Salabei JK

Amiodarone induced "Blue man syndrome"; an unusual presentation.

Heart & lung : the journal of critical care. 2020;49(2):202-203

Lakatos G, Nádházi Z, Igaz P, Rácz K

[The "blue man"].

Orvosi hetilap. 2013;154(51):2043-7

Rao U, Agarwal A

Amiodarone-induced facial pigmentation.

British journal of hospital medicine (London, England : 2005). 2012;73(8):473

Facchini G, Forte S, Podda P, Piro F, Carlone S

Pulmonary masses in a patient with blue-gray cutaneous hyperpigmentation.

European review for medical and pharmacological sciences. 2008;12(2):113-6

Enseleit F, Wyss CA, Duru F, Noll G, Ruschitzka F

Images in cardiovascular medicine. The blue man: amiodarone-induced skin discoloration.

Circulation. 2006;113(5):e63

Ostermaier R, Liese M, Matschke K, Pfeiffer C

[The face in not only coloured by blue blood].

Pneumologie (Stuttgart, Germany). 2005;59(8):533

Sendi P, Itin P

[What is your diagnosis? Pseudocyanosis due to amiodarone].

Praxis. 2004;93(42):1725-6

Ioannides MA, Moutiris JA, Zambartas C

A case of pseudocyanotic coloring of skin after prolonged use of amiodarone.

International journal of cardiology. 2003;90(2-3):345-6

Kounis NG, Frangides C, Papadaki PJ, Zavras GM, Goudevenos J

Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation.

Clinical cardiology. 1996;19(7):592-4