The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XI.g

Bluish, pseudocyanotic skin discoloration

Publications

Petreski T, Piko N, Privšek M, Zorman T, Bevc S

Blue Woman Syndrome and Thyrotoxicosis in a Patient on Amiodarone.

European journal of case reports in internal medicine 2020;7;001526 — 2020 — 001526

Fishman TJ, Spencer S, Harrell R, Salabei JK

Amiodarone induced "Blue man syndrome"; an unusual presentation.

Heart & lung : the journal of critical care 2019 Nov 25;; — 2019 Nov 25

Lakatos G, Nádházi Z, Igaz P, Rácz K

[The "blue man"].

Orvosi hetilap 2013 Dec 22;154;2043-7 — 2013 Dec 22 — 2043-7

Rao U, Agarwal A

Amiodarone-induced facial pigmentation.

British journal of hospital medicine (London, England : 2005) 2012 Aug;73;473 — 2012 Aug — 473

Facchini G, Forte S, Podda P, Piro F, Carlone S

Pulmonary masses in a patient with blue-gray cutaneous hyperpigmentation.

European review for medical and pharmacological sciences 2008 Mar-Apr;12;113-6 — 2008 Mar-Apr — 113-6

Enseleit F, Wyss CA, Duru F, Noll G, Ruschitzka F

Images in cardiovascular medicine. The blue man: amiodarone-induced skin discoloration.

Circulation 2006 Feb 07;113;e63 — 2006 Feb 07 — e63

Ostermaier R, Liese M, Matschke K, Pfeiffer C

[The face in not only coloured by blue blood].

Pneumologie (Stuttgart, Germany) 2005 Aug;59;533 — 2005 Aug — 533

Sendi P, Itin P

[What is your diagnosis? Pseudocyanosis due to amiodarone].

Praxis 2004 Oct 13;93;1725-6 — 2004 Oct 13 — 1725-6

Ioannides MA, Moutiris JA, Zambartas C

A case of pseudocyanotic coloring of skin after prolonged use of amiodarone.

International journal of cardiology 2003 Aug;90;345-6 — 2003 Aug — 345-6

Kounis NG, Frangides C, Papadaki PJ, Zavras GM, Goudevenos J

Dose-dependent appearance and disappearance of amiodarone-induced skin pigmentation.

Clinical cardiology 1996 Jul;19;592-4 — 1996 Jul — 592-4