The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.a

DRES syndrome - DRESS-like reaction

Before DRESS was named, the terms 'carbamazepine hypersensitivity syndrome' or 'anticonvulsant syndrome' were used

Publications

Shinoda T, Oki M, Kobayashi T, Ozawa H

Carbamazepine-Induced Drug-Induced Hypersensitivity Syndrome With Primary Adrenal Insufficiency: A Case Report.

The Tokai journal of experimental and clinical medicine 2026 Jul 20;51 — 2026 Jul 20 — 103-108

Irga N, Kosiak W, Jaworski R, Zielinski J, Adamkiewicz-Drozynska E

Pediatrician! Do you know the symptoms of DRESS syndrome? A case report of a 4-year-old girl.

Pediatric emergency care 2013 Apr;29;504-7 — 2013 Apr — 504-7

Buyuktiryaki AB, Bezirganoglu H, Sahiner UM, Yavuz ST, Tuncer A, Kara A, Sackesen C

Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl.

The Australasian journal of dermatology 2012 Nov;53;274-7 — 2012 Nov — 274-7

Giri PP, Roy S, Bhattyacharya S, Pal P, Dhar S

Dress syndrome with sepsis, acute respiratory distress syndrome and pneumomediastinum.

Indian journal of dermatology 2011 Nov;56;763-5 — 2011 Nov — 763-5

Halink DA, Marijnissen RM, Schut AA, Oude Voshaar RC

Drug reaction with eosinophilia and systemic symptoms induced by carbamazepine: DRESSed to kill.

General hospital psychiatry 2011 Jul-Aug;33;412.e5-8 — 2011 Jul-Aug — 412.e5-8

Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC

The DRESS syndrome: a literature review.

The American journal of medicine 2011 Jul;124;588-97 — 2011 Jul — 588-97

Seitz CS, Pfeuffer P, Raith P, Bröcker EB, Trautmann A

Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2006 Nov;97;698-702 — 2006 Nov — 698-702

Mesec A, Rot U, Perkovic T, Lunder T, Sibanc B

Carbamazepine hypersensitivity syndrome presenting as vasculitis of the CNS.

Journal of neurology, neurosurgery, and psychiatry 1999 Feb;66;249-50 — 1999 Feb — 249-50

Orliaguet O, Langin T, Gavazzi G, Brambilla C

[Acute eosinophilic pneumonia due to hypersensitivity to carbamazepine].

Revue des maladies respiratoires 1998 Dec;15;797-9 — 1998 Dec — 797-9

De Vriese AS, Philippe J, Van Renterghem DM, De Cuyper CA, Hindryckx PH, Matthys EG, Louagie A

Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature.

Medicine 1995 May;74;144-51 — 1995 May — 144-51

Lewis IJ, Rosenbloom L

Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine.

Postgraduate medical journal 1982 Feb;58;100-1 — 1982 Feb — 100-1

Paladini G, Marinig L

[Immuno-allergic side effects induced by the administration of carbamazepine. Case contribution].

Minerva medica 1984 Jun 30;75;1651-5 — 1984 Jun 30 — 1651-5

Houwerzijl J, De Gast GC, Nater JP, Esselink MT, Nieweg HO

Lymphocyte-stimulation tests and patch tests to carbamazepine hypersensitivity.

Clinical and experimental immunology 1977 Aug;29;272-7 — 1977 Aug — 272-7