The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.a

DRES syndrome - DRESS-like reaction

Before DRESS was named, the terms 'carbamazepine hypersensitivity syndrome' or 'anticonvulsant syndrome' were used

Publications

Shinoda T, Oki M, Kobayashi T, Ozawa H

Carbamazepine-Induced Drug-Induced Hypersensitivity Syndrome With Primary Adrenal Insufficiency: A Case Report.

The Tokai journal of experimental and clinical medicine. 2026;51(2):103-108

Irga N, Kosiak W, Jaworski R, Zielinski J, Adamkiewicz-Drozynska E

Pediatrician! Do you know the symptoms of DRESS syndrome? A case report of a 4-year-old girl.

Pediatric emergency care. 2013;29(4):504-7

Buyuktiryaki AB, Bezirganoglu H, Sahiner UM, Yavuz ST, Tuncer A, Kara A, Sackesen C

Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl.

The Australasian journal of dermatology. 2012;53(4):274-7

Giri PP, Roy S, Bhattyacharya S, Pal P, Dhar S

Dress syndrome with sepsis, acute respiratory distress syndrome and pneumomediastinum.

Indian journal of dermatology. 2011;56(6):763-5

Halink DA, Marijnissen RM, Schut AA, Oude Voshaar RC

Drug reaction with eosinophilia and systemic symptoms induced by carbamazepine: DRESSed to kill.

General hospital psychiatry. 2011;33(4):412.e5-8

Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, Roujeau JC

The DRESS syndrome: a literature review.

The American journal of medicine. 2011;124(7):588-97

Seitz CS, Pfeuffer P, Raith P, Bröcker EB, Trautmann A

Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2006;97(5):698-702

Mesec A, Rot U, Perkovic T, Lunder T, Sibanc B

Carbamazepine hypersensitivity syndrome presenting as vasculitis of the CNS.

Journal of neurology, neurosurgery, and psychiatry. 1999;66(2):249-50

Orliaguet O, Langin T, Gavazzi G, Brambilla C

[Acute eosinophilic pneumonia due to hypersensitivity to carbamazepine].

Revue des maladies respiratoires. 1998;15(6):797-9

De Vriese AS, Philippe J, Van Renterghem DM, De Cuyper CA, Hindryckx PH, Matthys EG, Louagie A

Carbamazepine hypersensitivity syndrome: report of 4 cases and review of the literature.

Medicine. 1995;74(3):144-51

Lewis IJ, Rosenbloom L

Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine.

Postgraduate medical journal. 1982;58(676):100-1

Paladini G, Marinig L

[Immuno-allergic side effects induced by the administration of carbamazepine. Case contribution].

Minerva medica. 1984;75(27):1651-5

Houwerzijl J, De Gast GC, Nater JP, Esselink MT, Nieweg HO

Lymphocyte-stimulation tests and patch tests to carbamazepine hypersensitivity.

Clinical and experimental immunology. 1977;29(2):272-7