The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Anai S, Nakayama Y, Gushiken H, Chinen S, Masuda K, Kamiya H, Ueno S, Maeda M, Kiyuna M, Sato Y, Matsumoto T

Diffuse alveolar hemorrhage and acute eosinophilic pneumonia: A rare form of amiodarone pulmonary toxicity diagnosed by bronchoalveolar lavage.

Journal of cardiology cases. 2023;27(3):93-96

Alexandre AT, Vale A, Gomes T

Diffuse alveolar hemorrhage: how relevant is etiology?

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 2019;36(1):47-52

Papanikolaou IC, Makou I, Markatis E

Amiodarone and diffuse alveolar hemorrhage.

Advances in respiratory medicine. 2020;88(2):169-171

Saeed J, Waqas QA, Khan UI, Abdullah HMA

Amiodarone-induced diffuse alveolar haemorrhage: a rare but potentially life-threatening complication of a commonly prescribed medication.

BMJ case reports. 2019;12(10)

Blasco LM

Trepopnea due to amiodarone-induced diffuse alveolar hemorrhage.

Respiratory care. 2013;58(2):e11-3

Borders CW 3rd, Bennett S, Mount C, Claassen SL

A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report.

Military medicine. 2012;177(1):118-20

Tanawuttiwat T, Harindhanavudhi T, Hanif S, Sahloul MZ

Amiodarone-induced alveolar haemorrhage: a rare complication of a common medication.

Heart, lung & circulation. 2010;19(7):435-7

Iskander S, Raible DG, Brozena SC, Gaitanaru DM, Ayala G, Iskandrian AE

Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions. 1999;47(1):61-3