The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.o

Path: Endogenous lipoid pneumonia (phospholipidosis)

Publications

Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T

Severe amiodarone induced pulmonary toxicity.

Journal of thoracic disease 2012 Dec;4;667-70 — 2012 Dec — 667-70

Salaün M, Roussel F, Bourg-Heckly G, Vever-Bizet C, Dominique S, Genevois A, Jounieaux V, Zalcman G, Bergot E, Vergnon JM, Thiberville L

In vivo probe-based confocal laser endomicroscopy in amiodarone-related pneumonia.

The European respiratory journal 2013 Dec;42;1646-58 — 2013 Dec — 1646-58

Larsen BT, Vaszar LT, Colby TV, Tazelaar HD

Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.

The American journal of surgical pathology 2012 Apr;36;509-16 — 2012 Apr — 509-16

Koschel D, Handzhiev S, Leucht V, Holotiuk O, Fisseler-Eckhoff A, Höffken G

Hypersensitivity pneumonitis associated with the use of temozolomide.

The European respiratory journal 2009 Apr;33;931-4 — 2009 Apr — 931-4

Ruangchira-Urai R, Colby TV, Klein J, Nielsen GP, Kradin RL, Mark EJ

Nodular amiodarone lung disease.

The American journal of surgical pathology 2008 Nov;32;1654-60 — 2008 Nov — 1654-60

Wang CW, Colby TV

Histiocytic lesions and proliferations in the lung.

Seminars in diagnostic pathology 2007 Aug;24;162-82 — 2007 Aug — 162-82

Wang T, Charette S, Smith MI

An unintended consequence: fatal amiodarone pulmonary toxicity in an older woman.

Journal of the American Medical Directors Association 2006 Oct;7;510-3 — 2006 Oct — 510-3

Kharabsheh S, Abendroth CS, Kozak M

Fatal pulmonary toxicity occurring within two weeks of initiation of amiodarone.

The American journal of cardiology 2002 Apr 01;89;896-8 — 2002 Apr 01 — 896-8

Bedrossian CW, Warren CJ, Ohar J, Bhan R

Amiodarone pulmonary toxicity: cytopathology, ultrastructure, and immunocytochemistry.

Annals of diagnostic pathology 1997 Oct;1;47-56 — 1997 Oct — 47-56

Marchlinski FE, Gansler TS, Waxman HL, Josephson ME

Amiodarone pulmonary toxicity.

Annals of internal medicine 1982 Dec;97;839-45 — 1982 Dec — 839-45

Gefter WB, Epstein DM, Pietra GG, Miller WT

Lung disease caused by amiodarone, a new antiarrythmic agent.

Radiology 1983 May;147;339-44 — 1983 May — 339-44

Adams PC, Gibson GJ, Morley AR, Wright AJ, Corris PA, Reid DS, Campbell RW

Amiodarone pulmonary toxicity: clinical and subclinical features.

The Quarterly journal of medicine 1986 May;59;449-71 — 1986 May — 449-71

Dake MD, Madison JM, Montgomery CK, Shellito JE, Hinchcliffe WA, Winkler ML, Bainton DF

Electron microscopic demonstration of lysosomal inclusion bodies in lung, liver, lymph nodes, and blood leukocytes of patients with amiodarone pulmonary toxicity.

The American journal of medicine 1985 Mar;78;506-12 — 1985 Mar — 506-12

Ren H, Kuhlman JE, Hruban RH, Fishman EK, Wheeler PS, Hutchins GM

CT-pathology correlation of amiodarone lung.

Journal of computer assisted tomography 1990 Sep-Oct;14;760-5 — 1990 Sep-Oct — 760-5

Nicolet-Chatelain G, Prevost MC, Escamilla R, Migueres J

Amiodarone-induced pulmonary toxicity. Immunoallergologic tests and bronchoalveolar lavage phospholipid content.

Chest 1991 Feb;99;363-9 — 1991 Feb — 363-9