The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.f

Path: Diffuse alveolar damage (DAD-pattern) (see also IL)

Publications

Torimitsu T, Yoshida T, Makiuchi S, Itoh H, Oya M

Amiodarone-induced multiple organ damage in an Alström syndrome patient with end-stage renal disease and hepatic cirrhosis.

CEN case reports 2021 Jul 05;; — 2021 Jul 05

Nacca N, Bhamidipati CM, Yuhico LS, Pinnamaneni S, Szombathy T

Severe amiodarone induced pulmonary toxicity.

Journal of thoracic disease 2012 Dec;4;667-70 — 2012 Dec — 667-70

Borders CW, Bennett S, Mount C, Claassen SL

A rare case of acute diffuse alveolar hemorrhage following initiation of amiodarone: a case report.

Military medicine 2012 Jan;177;118-20 — 2012 Jan — 118-20

Larsen BT, Vaszar LT, Colby TV, Tazelaar HD

Lymphoid hyperplasia and eosinophilic pneumonia as histologic manifestations of amiodarone-induced lung toxicity.

The American journal of surgical pathology 2012 Apr;36;509-16 — 2012 Apr — 509-16

Sobol SM, Rakita L

Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug.

Circulation 1982 Apr;65;819-24 — 1982 Apr — 819-24

Jirik FR, Henning H, Huckell VF, Ostrow DV

Diffuse alveolar damage syndrome associated with amiodarone therapy.

Canadian Medical Association journal 1983 May 15;128;1192-5 — 1983 May 15 — 1192-5

Colgan T, Simon GT, Kay JM, Pugsley SO, Eydt J

Amiodarone pulmonary toxicity.

Ultrastructural pathology 1984;6;199-207 — 1984 — 199-207

Saussine M, Colson P, Alauzen M, Mary H

Postoperative acute respiratory distress syndrome. A complication of amiodarone associated with 100 percent oxygen ventilation.

Chest 1992 Sep;102;980-1 — 1992 Sep — 980-1