The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.k

Lung nodule or nodules

Publications

Eyselbergs M, Pilate I, Rombouts H, Vanhoenacker FM

Amiodarone induced pulmonary toxicity mimicking malignancy at initial presentation.

JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR). 2012;95(2):109

Kimura T, Kuramochi S, Katayama T, Yoshikawa T, Yamada T, Ueda Y, Okada Y

Amiodarone-related pulmonary mass and unique membranous glomerulonephritis in a patient with valvular heart disease: Diagnostic pitfall and new findings.

Pathology international. 2008;58(10):657-63

Ruangchira-Urai R, Colby TV, Klein J, Nielsen GP, Kradin RL, Mark EJ

Nodular amiodarone lung disease.

The American journal of surgical pathology. 2008;32(11):1654-60

Jarand J, Lee A, Leigh R

Amiodaronoma: an unusual form of amiodarone-induced pulmonary toxicity.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 2007;176(10):1411-3

Azzam I, Tov N, Elias N, Naschitz JE

Amiodarone toxicity presenting as pulmonary mass and peripheral neuropathy: the continuing diagnostic challenge.

Postgraduate medical journal. 2006;82(963):73-5

Chouri N, Langin T, Lantuejoul S, Coulomb M, Brambilla C

Pulmonary nodules with the CT halo sign.

Respiration; international review of thoracic diseases. 2002;69(1):103-6

Rodríguez-García JL, García-Nieto JC, Ballesta F, Prieto E, Villanueva MA, Gallardo J

Pulmonary mass and multiple lung nodules mimicking a lung neoplasm as amiodarone-induced pulmonary toxicity.

European journal of internal medicine. 2001;12(4):372-376

de Granda Orive JI, Herrera de la Rosa A, Martínez Albiach JM, Escobar Sacristán JA, Sáez Valls R, Gallego Rodríguez V

[Amiodarone pulmonary toxicity: radiological coexistence of nodules with interstitial and alveolar abnormalities].

Anales de medicina interna (Madrid, Spain : 1984). 1998;15(5):267-9

Criée CP, Wilhelms E, Kneba M, Kreuzer H

[Formation of multiple round foci in the lung during amiodarone therapy].

Deutsche medizinische Wochenschrift (1946). 1984;109(13):499-500

Standertskjöld-Nordenstam CG, Wandtke JC, Hood WB Jr, Zugibe FT, Butler L

Amiodarone pulmonary toxicity. Chest radiography and CT in asymptomatic patients.

Chest. 1985;88(1):143-5

Patel P, Honeybourne D, Watson RD

Amiodarone-induced pulmonary toxicity mimicking metastatic lung disease.

Postgraduate medical journal. 1987;63(739):393-4

Arnon R, Raz I, Chajek-Shaul T, Berkman N, Fields S, Bar-On H

Amiodarone pulmonary toxicity presenting as a solitary lung mass.

Chest. 1988;93(2):425-7

Piccione W Jr, Faber LP, Rosenberg MS

Amiodarone-induced pulmonary mass.

The Annals of thoracic surgery. 1989;47(6):918-9