The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.d

Path: Acute fibrinous organizing pneumonia (AFOP-pattern) (see also pattern If)

Publications

Kugasia IR, Ijaz M, Khan A, Jasti Y

Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis.

The American journal of case reports. 2020;21:e926929

Beasley MB, Franks TJ, Galvin JR, Gochuico B, Travis WD

Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage.

Archives of pathology & laboratory medicine. 2002;126(9):1064-70

Colgan T, Simon GT, Kay JM, Pugsley SO, Eydt J

Amiodarone pulmonary toxicity.

Ultrastructural pathology. 1984;6(2-3):199-207