The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Cough (lone)
Amiodarone-associated cough typically annunciates or is a presenting feature of amiodarone-induced pulmonary toxicity
Publications
48-Year-old woman with dyspnea, cough, and weight loss.
Mayo Clinic proceedings 2012 Nov;87;1124-7 — 2012 Nov — 1124-7
Pulmonary toxicity in patients receiving low-dose amiodarone.
Chest 2003 Feb;123;646-51 — 2003 Feb — 646-51