The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.t

Heart block (bundle branch- or AV-)

Publications

Leslie PJ, Heyworth R, Prescott LF

Cardiac complications of carbamazepine intoxication: treatment by haemoperfusion.

British medical journal (Clinical research ed.) 1983 Mar 26;286;1018 — 1983 Mar 26 — 1018

Benassi E, Bo GP, Cocito L, Maffini M, Loeb C

Carbamazepine and cardiac conduction disturbances.

Annals of neurology 1987 Aug;22;280-1 — 1987 Aug — 280-1

Kasarskis EJ, Kuo CS, Berger R, Nelson KR

Carbamazepine-induced cardiac dysfunction. Characterization of two distinct clinical syndromes.

Archives of internal medicine 1992 Jan;152;186-91 — 1992 Jan — 186-91