The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.n

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Tziatzios GD, Didagelos M, Tziatzios I, Hadjimiltiades S, Karamitsos T

Torsades de Pointes and Prolonged Self-Terminating Ventricular Fibrillation Induced by Amiodarone.

Cureus 2020 Nov 25;12;e11693 — 2020 Nov 25 — e11693

Han D, Tan H, Sun C, Li G

Amiodarone-induced life-threatening torsade de pointes in an end-stage lung cancer patient receiving gefitinib.

Oxford medical case reports 2019 Jan;2019;omy122 — 2019 Jan — omy122

Brooks MJ, Pattison DA, Teo EP, Price S, Gurvitch R

Amiodarone-induced destructive thyroiditis associated with coronary artery vasospasm and recurrent ventricular fibrillation.

European thyroid journal 2013 Mar;2;65-7 — 2013 Mar — 65-7