The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.o

Cardiovascular collapse - Cardiogenic shock - Hypotension

Essentially seen following i.v. amiodarone. May be to to excipient, notably the solvent benzyl alcohol

Publications

Lindquist DE, Rowe AS, Heidel E, Fleming T, Yates JR

Evaluation of the Hemodynamic Effects of Intravenous Amiodarone Formulations During the Maintenance Phase Infusion.

The Annals of pharmacotherapy 2015 Dec;49;1317-21 — 2015 Dec — 1317-21

Doshi D, Jayawardana R

Amiodarone-Induced Life-Threatening Refractory Hypotension.

The American journal of case reports 2015 Sep 14;16;617-20 — 2015 Sep 14 — 617-20

Saharan S, Balaji S

Cardiovascular collapse during amiodarone infusion in a hemodynamically compromised child with refractory supraventricular tachycardia.

Annals of pediatric cardiology 2015 Jan-Apr;8;50-2 — 2015 Jan-Apr — 50-2

Masi S, de Cléty SC, Anslot C, Detaille T

Acute amiodarone toxicity due to an administration error: could excipient be responsible?

British journal of clinical pharmacology 2009 Jun;67;691-3 — 2009 Jun — 691-3