The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

I??k P, Çetin I, Tavil B, Azik F, Kara A, Yarali N, Tunc B

All-transretinoic acid (ATRA) treatment-related pancarditis and severe pulmonary edema in a child with acute promyelocytic leukemia.

Journal of pediatric hematology/oncology 2010 Nov;32;e346-8 — 2010 Nov — e346-8

Jung JI, Choi JE, Hahn ST, Min CK, Kim CC, Park SH

Radiologic features of all-trans-retinoic acid syndrome.

AJR. American journal of roentgenology 2002 Feb;178;475-80 — 2002 Feb — 475-80