The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Tamaru S, Tono Y, Matsumoto T, Oda H, Sugimoto Y, Mizuno T, Katayama N, Nishikawa M

Successful treatment by prednisolone for interstitial pneumonia associated with anagrelide in a patient with essential thrombocythemia.

International cancer conference journal 2017 Jan;6 — 2017 Jan — 22-24

Spencer EM, Lawrence DS

'Double hit' from streptococcal pneumonia and hypersensitivity pneumonitis associated with anagrelide.

Clinical and laboratory haematology 2006 Feb;28;63-5 — 2006 Feb — 63-5

Raghavan M, Mazer MA, Brink DJ

Severe hypersensitivity pneumonitis associated with anagrelide.

The Annals of pharmacotherapy 2003 Sep;37;1228-31 — 2003 Sep — 1228-31