The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

Publications

Stuart MJ, Chao NS, Horning SJ, Wong RM, Negrin RS, Johnston LJ, Shizuru JA, Long GD, Blume KG, Stockerl-Goldstein KE

Efficacy and toxicity of a CCNU-containing high-dose chemotherapy regimen followed by autologous hematopoietic cell transplantation in relapsed or refractory Hodgkin's disease.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2001;7(10):552-60

Aronin PA, Mahaley MS Jr, Rudnick SA, Dudka L, Donohue JF, Selker RG, Moore P

Prediction of BCNU pulmonary toxicity in patients with malignant gliomas: an assessment of risk factors.

The New England journal of medicine. 1980;303(4):183-8

Lieberman A, Ruoff M, Estey E, Seidman I, Lieberman I, Wise A

Irreversible pulmonary toxicity after single course of BCNU.

The American journal of the medical sciences. 1980;279(1):53-6

Mitsudo SM, Greenwald ES, Banerji B, Koss LG

BCNU (1,3-bis-(2-chloroethyl)-1-nitrosurea) lung. Drug-induced pulmonary changes.

Cancer. 1984;54(4):751-5

Weiss RB, Shah S, Shane SR

Pulmonary toxicity from carmustine (BCNU): a case report.

Medical and pediatric oncology. 1979;6(3):255-9

Richter JE, Hastedt R, Dalton JF, Marshall D, Raymond LW

Pulmonary toxicity of bischloronitrosourea: report of a case with transient response to corticosteroid therapy.

Cancer. 1979;43(5):1607-12

Bellot PA, Valdiserri RO

Multiple pulmonary lesions in a patient treated with BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) for glioblastoma multiforme.

Cancer. 1979;43(1):46-50