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The Drug-Induced Respiratory Disease Website and App

I.t

I - Interstitial/parenchymal lung disease

Pneumoconiosis (silicosis, talcosis...)

Last update 11/09/2026

(Fr: pneumoconiose-talcose). Mineral dust-induced lung disease. Mainly due to exposure to drugs (mostly abused) containing silica or talc. Not unlike occupational silicosis, large airway involvement remains a possibility (PMID 18583512)

Causative drugs

10

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

Abused drugs/substances (illicit-, street drugs - IV/inhaled)
I.c
I.e
I.j
I.m
I.s
I.t
II.a
II.b
III.a
IV.a
IV.f
IV.g
V.f
V.q
V.ab
VI.b
VI.c
VI.g
VI.i
VI.j
VI.r
VI.t
VII.h
VII.i
VIII.c
VIII.d
VIII.ai
IX.a
IX.s
IX.ah
X.m
X.u
X.ac
X.bb
XI.b
XI.g
XI.j
XI.n
XII.g
XII.i
XII.v
XV.q
XV.s
XV.v
XV.ag
XV.al
XVI.d
XVI.u
XVI.v
XVI.ab
XVI.ae
XVI.af
XVI.ai
XVII.a
XVII.b
XVII.g
XVII.p
XVII.s
XVII.u
XVII.al
XVIII.t
XVIII.u
XVIII.x
Cocaine
I.c
I.d
I.e
I.t
I.z
II.a
II.d
III.a
III.b
III.c
III.n
IV.a
IV.f
IV.o
V.f
V.ab
VI.a
VI.b
VI.l
VII.h
VIII.a
VIII.c
VIII.i
VIII.m
VIII.w
VIII.ah
VIII.ai
VIII.ak
VIII.ap
VIII.aw
IX.k
IX.o
X.f
X.h
X.j
X.m
X.o
X.s
X.u
X.x
X.ac
X.ad
X.as
XI.b
XI.j
XI.k
XI.n
XI.aa
XI.at
XII.a
XII.e
XII.f
XII.g
XII.l
XII.y
XII.ae
XII.af
XII.aj
XII.ap
XIV.c
XV.b
XV.g
XV.h
XV.s
XV.w
XV.aw
XVI.k
XVII.b
Excipients-Vehicle-Preservatives (of drugs)
I.c
I.d
I.e
I.g
I.m
I.t
II.a
IV.a
IV.f
IV.i
VI.b
VI.e
VI.g
X.f
X.g
X.u
X.bh
XI.d
XII.n
XV.q
XV.ae
XVI.q
XVI.v
Marijuana, cannabis (haschish, hash, bang, dab)
I.a
I.c
I.e
I.j
I.n
I.t
I.an
I.ao
II.b
III.a
III.c
IV.a
IV.d
V.a
V.f
V.ab
VII.h
VIII.w
VIII.ax
IX.d
X.f
X.ac
XI.b
XI.j
XI.o
XI.ar
XII.c
XII.d
XII.g
XII.l
XII.s
XII.w
XII.af
XII.ap
XIII.a
XV.k
XV.n
XV.p
XV.q
XV.s
XV.v
XVI.m
XVI.ai
XVII.a
XVII.c
XVII.g
Mephenidate (Methylphenidate)
I.c
I.t
IV.n
V.f
VI.b
VI.g
IX.k
X.m
X.bb
XI.b
XI.j
XII.g
XV.b
XV.q
Methadone
I.t
II.a
II.b
II.f
VI.b
VI.g
IX.c
IX.d
IX.e
IX.i
XI.n
XII.e
XII.f
XII.l
XII.p
XII.t
XII.bn
Methamphetamine
I.a
I.t
II.a
II.b
II.v
III.a
IV.a
VI.b
VII.h
VIII.ae
IX.t
IX.ae
X.m
X.u
XI.b
XI.n
XII.f
XII.g
XII.ba
XII.bw
XV.q
Pentazocine
I.t
II.a
VI.b
VI.g
VI.i
VI.n
IX.d
IX.h
IX.l
XI.n
XV.q
XXVII.a
Silica, crystalline
I.t
Talc (inhaled, sniffed, i.v., intrapleural)
I.d
I.t
II.b
II.f
IV.c
IV.i
IV.m
V.c
V.r
VI.b
VI.g
VII.f
VII.n
X.f
XI.b
XI.q
XV.e
XV.q
XV.s
XV.ag
XV.da
XVI.w
XVI.ae
XVI.bm
XVIII.i
XIX.k