The Drug-Induced Respiratory Disease Website and App

Talc (inhaled, sniffed, i.v., intrapleural)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.t

Pneumoconiosis (silicosis, talcosis...)

Publications

Verlynde G, Agneessens E, Dargent JL

Pulmonary Talcosis Due to Daily Inhalation of Talc Powder.

Journal of the Belgian Society of Radiology. 2018;102(1):12

Baylor PA, Sobenes JR, Vallyathan V

Interstitial pulmonary fibrosis and progressive massive fibrosis related to smoking methamphetamine with talc as filler.

Respiratory care. 2013;58(5):e53-5

van Huisstede A, Noordhoek Hegt V, Otte-Holler I, Looijen-Salamon M, Rudolphus A

Talcosis due to abundant use of cosmetic talcum powder.

European respiratory review : an official journal of the European Respiratory Society. 2010;19(116):165-8

Marchiori E, Lourenço S, Gasparetto TD, Zanetti G, Mano CM, Nobre LF

Pulmonary talcosis: imaging findings.

Lung. 2010;188(2):165-71

Paré JA, Fraser RG, Hogg JC, Howlett JG, Murphy SB

Pulmonary 'mainline' granulomatosis: talcosis of intravenous methadone abuse.

Medicine. 1979;58(3):229-39