The Drug-Induced Respiratory Disease Website and App

Silica, crystalline

Crystalline silica is a very common and large scale aerocontaminant in underground or open mines, grinding/sandblasting, artificial/Caesar stone industry/jobs, jewelry, dental prosthesis manufacture, and blue jean processing/sandblasting (depending on countries) (PMID 31517432; 31989662). As of drugs, cristalline silica can be present in drug tablets and pills that can be crushed and auto-injected by some addicts, and/or as a cutting agent or adulterant in inhaled cocaine, marijuana, and household cleasning agents.

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.u

Pneumoconiosis (silicosis, talcosis...)