The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.b

Pulmonary arterial hypertension

Publications

Karaman MG, Atalay F, Tufan AE, Erdogan A

Pulmonary arterial hypertension in an adolescent treated with methylphenidate.

Journal of child and adolescent psychopharmacology 2010 Jun;20;229-31 — 2010 Jun — 229-31

Tomashefski JF, Hirsch CS

The pulmonary vascular lesions of intravenous drug abuse.

Human pathology 1980 Mar;11;133-45 — 1980 Mar — 133-45

Lundquest DE, Young WK, Edland JF

Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.

Journal of forensic sciences 1987 May;32;798-801 — 1987 May — 798-801