The Drug-Induced Respiratory Disease Website and App

Talc (inhaled, sniffed, i.v., intrapleural)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

V.c

Pleural thickening - Fibrothorax

Publications

Hemdan Abdalla AM, White D

A 29-year-old woman with a remote history of osteosarcoma and positron emission tomography-positive pleurally based masses. Talcomas secondary to prior talc pleurodesis.

Chest. 2008;134(3):640-643

Ahmadzadehfar H, Palmedo H, Strunk H, Biersack HJ, Habibi E, Ezziddin S

False positive 18F-FDG-PET/CT in a patient after talc pleurodesis.

Lung cancer (Amsterdam, Netherlands). 2007;58(3):418-21

Kwek BH, Aquino SL, Fischman AJ

Fluorodeoxyglucose positron emission tomography and CT after talc pleurodesis.

Chest. 2004;125(6):2356-60