The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.l

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Solhjoo S, Punjabi NM, Ivanescu AE, Crainiceanu C, Gaynanova I, Wicken C, Buckenmaier C 3rd, Haigney MC

Methadone Destabilizes Cardiac Repolarization During Sleep.

Clinical pharmacology and therapeutics. 2021;110(4):1066-1074

Aghabiklooei A, Edalatparvar M, Zamani N, Mostafazadeh B

Prognostic factors in acute methadone toxicity: a 5-year study.

Journal of toxicology. 2014;2014:341826

Rajpal S, Mundi AS, Reddy PC, Akkus NI

Treatment of methadone-induced torsades de pointes with lidocaine.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 2013;165(6):338-41

Modesto-Lowe V, Brooks D, Petry N

Methadone deaths: risk factors in pain and addicted populations.

Journal of general internal medicine. 2010;25(4):305-9