Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website and App

Methadone

See also PMID 19720472 & 21261690

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.u

Pneumoconiosis (silicosis, talcosis...)

II - Pulmonary edema - Acute lung injury - ARDS

II.a

Pulmonary edema, noncardiogenic (NCPE)
II.e

ARDS - Acute lung injury
II.h

Hypoxemia, low oxygen saturation (may occur in isolation)

VII - Pulmonary vasculopathy

VII.b

Pulmonary arterial hypertension
VII.g

Foreign body pulmonary vasculopathy (Excipient lung disease)

IX - Neuromuscular / CNS involvement - Disordered breathing (during sleep)

IX.c

Chest wall muscle rigidity - Stiff/wooden chest
IX.d

Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)
IX.e

Disordered breathing pattern incl. Cheyne-Stokes respiration
IX.i

Respiratory arrest - Apnea

XI - Miscellaneous

XI.o

Death following exposure or poisoning

XII - Cardiovascular involvement / toxicity

XII.f

Takotsubo (stress) cardiomyopathy
XII.g

Cardiomyopathy (acute, subacute, chronic)
XII.n

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
XII.q

QTc prolongation
XII.v

Torsades de pointe
XII.bq

Right ventricular dysfunction.failure