The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Alghamdi D, Jahdali H, Alharbi A, Alshehri A, Alfirm B, Bamefleh H

Methylphenidate causes chronic eosinophilic pneumonia.

Annals of thoracic medicine 2024;19 — 2024 — 112-115

Wolf J, Fein A, Fehrenbacher L

Eosinophilic syndrome with methylphenidate abuse.

Annals of internal medicine 1978 Aug;89;224-5 — 1978 Aug — 224-5