The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.t

Torsades de pointe

Publications

Alinejad S, Kazemi T, Zamani N, Hoffman RS, Mehrpour O

A systematic review of the cardiotoxicity of methadone.

EXCLI journal. 2015;14:577-600

Romero J, Baldinger SH, Goodman-Meza D, Engstrom K, Valencia CR, Golive A, Medrano F, Rangasamy S, Makkiya M, Fisher JD, Gross J, Krumerman A, Kim S, Garcia MJ, Di Biase L, Ferrick KJ

Drug-induced torsades de pointes in an underserved urban population. Methadone: is there therapeutic equipoise?

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing. 2016;45(1):37-45

Khalesi S, Shemirani H, Dehghani-Tafti F

Methadone induced torsades de pointes and ventricular fibrillation: A case review.

ARYA atherosclerosis. 2014;10(6):339-42

Rajpal S, Mundi AS, Reddy PC, Akkus NI

Treatment of methadone-induced torsades de pointes with lidocaine.

The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 2013;165(6):338-41