The Drug-Induced Respiratory Disease Website and App

Talc (inhaled, sniffed, i.v., intrapleural)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XV.ag

Path: Foreign body embolism, microangiopathy, vasculopathy

Publications

Weiner J, Chandak T, Caperna A, Malieckal D, Xu W, Reder I, Shah R

Diffuse talc granulomatosis in a patient with Crohn's disease.

American journal of respiratory and critical care medicine. 2012;186(7):e11

Griffith CC, Raval JS, Nichols L

Intravascular Talcosis due to Intravenous Drug Use Is an Underrecognized Cause of Pulmonary Hypertension.

Pulmonary medicine. 2012;2012:617531

WENDT VE, PURO HE, SHAPIRO J, MATHEWS W, WOLF PL

ANGIOTHROMBOTIC PULMONARY HYPERTENSION IN ADDICTS. "BLUE VELVET" ADDICTION.

JAMA. 1964;188:755-7

Genereux GP, Emson HE

Talc granulomatosis and angiothrombotic pulmonary hypertension in drug addicts.

Journal of the Canadian Association of Radiologists. 1974;25(2):87-93