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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.b

ARDS - Acute lung injury

A complication of intrapleural talc (talc poudrage)

Publications

Gonzalez AV, Bezwada V, Beamis JF Jr, Villanueva AG

Lung injury following thoracoscopic talc insufflation: experience of a single North American center.

Chest. 2010;137(6):1375-81

Griffo S, Musumeci A, De Luca G, Saccenti A, Grande LM, Stassano P

Talc-induced interstitial pneumonitis with respiratory failure.

Anaesthesia and intensive care. 2009;37(1):127-9

Kuzniar TJ, Blum MG, Kasibowska-Kuzniar K, Mutlu GM

Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis.

The Annals of thoracic surgery. 2006;82(6):1976-81

Ghio AJ, Roggli V, Light RW

Talc should not be used for pleurodesis in patients with nonmalignant pleural effusions.

American journal of respiratory and critical care medicine. 2001;164(9):1741; author reply 1741

Rinaldo JE, Owens GR, Rogers RM

Adult respiratory distress syndrome following intrapleural instillation of talc.

The Journal of thoracic and cardiovascular surgery. 1983;85(4):523-6

Bouchama A, Chastre J, Gaudichet A, Soler P, Gibert C

Acute pneumonitis with bilateral pleural effusion after talc pleurodesis.

Chest. 1984;86(5):795-7