The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
ARDS - Acute lung injury
A complication of intrapleural talc (talc poudrage)
Publications
Lung injury following thoracoscopic talc insufflation: experience of a single North American center.
Chest 2010 Jun;137;1375-81 — 2010 Jun — 1375-81
Talc-induced interstitial pneumonitis with respiratory failure.
Anaesthesia and intensive care 2009 Jan;37;127-9 — 2009 Jan — 127-9
Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis.
The Annals of thoracic surgery 2006 Dec;82;1976-81 — 2006 Dec — 1976-81
Talc should not be used for pleurodesis in patients with nonmalignant pleural effusions.
American journal of respiratory and critical care medicine 2001 Nov 01;164;1741; author reply 1741 — 2001 Nov 01 — 1741; author reply 1741
Adult respiratory distress syndrome following intrapleural instillation of talc.
The Journal of thoracic and cardiovascular surgery 1983 Apr;85;523-6 — 1983 Apr — 523-6
Acute pneumonitis with bilateral pleural effusion after talc pleurodesis.
Chest 1984 Nov;86;795-7 — 1984 Nov — 795-7