The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Hypoxemia, low oxygen saturation (may occur in isolation)
Publications
Medical outcomes associated with nonmedical use of methadone and buprenorphine.
The Journal of emergency medicine 2013 Aug;45;199-205 — 2013 Aug — 199-205
Improvement in hepatopulmonary syndrome after methadone withdrawal: a case report with implications for disease mechanism.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2010 Jul;16;870-3 — 2010 Jul — 870-3