The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Path: Foreign body deposits/granulomatous reaction
Publications
Fatal Excipients: An Autopsy Case Series of Excipient Lung Disease.
The American journal of forensic medicine and pathology 2022 Mar 01;43;81-89 — 2022 Mar 01 — 81-89
Rapid development of pulmonary hypertension and right ventricular failure due to large vessel intravascular microcrystalline cellulosis in an intravenous drug user.
Pulmonary circulation 2020 Jan-Mar;10;2045894020907871 — 2020 Jan-Mar — 2045894020907871
Pulmonary hypertension and foreign body granulomas in intravenous drug abusers. Documentation by cardiac catheterization and lung biopsy.
The American journal of medicine 1976 Nov;61;657-64 — 1976 Nov — 657-64