The Drug-Induced Respiratory Disease Website and App

Talc (inhaled, sniffed, i.v., intrapleural)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.s

Pleural mass or masses

Typically, talc-induced pleural masses are tracer-avid on 18F-dideoxyglusose PET scan and may mimic pleural neoplasms

Publications

Fanggiday JC, Rouse RW, Collard SM, de Haas MJ, de Klerk JM

Persistent Inflammation in Pulmonary Granuloma 48 Years after Talcage Pleurodesis, Detected by FDG-PET/CT.

Case reports in medicine 2012;2012;686153 — 2012 — 686153

Ahmadzadehfar H, Palmedo H, Strunk H, Biersack HJ, Habibi E, Ezziddin S

False positive 18F-FDG-PET/CT in a patient after talc pleurodesis.

Lung cancer (Amsterdam, Netherlands) 2007 Dec;58;418-21 — 2007 Dec — 418-21

Kwek BH, Aquino SL, Fischman AJ

Fluorodeoxyglucose positron emission tomography and CT after talc pleurodesis.

Chest 2004 Jun;125;2356-60 — 2004 Jun — 2356-60

Murray JG, Erasmus JJ, Bahtiarian EA, Goodman PC

Talc pleurodesis simulating pleural metastases on 18F-fluorodeoxyglucose positron emission tomography.

AJR. American journal of roentgenology 1997 Feb;168;359-60 — 1997 Feb — 359-60