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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VII.h

Pneumomediastinum

PMID 34479899

Publications

Iqbal M, Hussain A, Majeed Z, Elfaki H

Pneumomediastinum in a cannabis smoker precipitated by vigorous sexual intercourse.

BMJ case reports. 2021;14(9)

Puri C, Rhee K, Harish VK, Slack D

Marijuana induced spontaneous pneumomediastinum.

Journal of community hospital internal medicine perspectives. 2021;11(4):516-517

Weiss ZF, Gore S, Foderaro A

Pneumomediastinum in marijuana users: a retrospective review of 14 cases.

BMJ open respiratory research. 2019;6(1):e000391

Iyer VN, Joshi AY, Ryu JH

Spontaneous pneumomediastinum: analysis of 62 consecutive adult patients.

Mayo Clinic proceedings. 2009;84(5):417-21