The Drug-Induced Respiratory Disease Website and App

Excipients-Vehicle-Preservatives (of drugs)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Levy Y, Segal N, Nahum A, Marcus N, Garty BZ

Hypersensitivity to methylprednisolone sodium succinate in children with milk allergy.

The journal of allergy and clinical immunology. In practice. 2014;2(4):471-4

Roncati L, Barbolini G, Scacchetti AT, Busani S, Maiorana A

Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient.

Forensic science international. 2013;228(1-3):e28-32

You BC, Jang AS, Han JS, Cheon HW, Park JS, Lee JH, Park SW, Kim DJ, Park CS

A case of propofol-induced oropharyngeal angioedema and bronchospasm.

Allergy, asthma & immunology research. 2012;4(1):46-8