The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLVI.b

Pulmonary arterial hypertension

Publications

Houck RJ, Bailey GL, Daroca PJ, Brazda F, Johnson FB, Klein RC

Pentazocine abuse. Report of a case with pulmonary arterial cellulose granulomas and pulmonary hypertension.

Chest 1980 Feb;77;227-30 — 1980 Feb — 227-30

Farber HW, Falls R, Glauser FL

Transient pulmonary hypertension from the intravenous injection of crushed, suspended pentazocine tablets.

Chest 1981 Aug;80;178-82 — 1981 Aug — 178-82

Lundquest DE, Young WK, Edland JF

Maternal death associated with intravenous methylphenidate (Ritalin) and pentazocine (Talwin) abuse.

Journal of forensic sciences 1987 May;32;798-801 — 1987 May — 798-801