The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLI.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Eizadi-Mood N, Naeini SA, Hedaiaty M, Sabzghabaee AM, Moudi M

Prevalence of pulmonary edema among the deceased cases with acute Methadone poisoning: A report from Iran.

Journal of research in pharmacy practice 2016 Oct-Dec;5;290-293 — 2016 Oct-Dec — 290-293

Winklhofer S, Surer E, Ampanozi G, Ruder T, Stolzmann P, Elliott M, Oestreich A, Kraemer T, Thali M, Alkadhi H, Schweitzer W

Post-mortem whole body computed tomography of opioid (heroin and methadone) fatalities: frequent findings and comparison to autopsy.

European radiology 2014 Jun;24;1276-82 — 2014 Jun — 1276-82

Daugherty LE

Extracorporeal membrane oxygenation as rescue therapy for methadone-induced pulmonary edema.

Pediatric emergency care 2011 Jul;27;633-4 — 2011 Jul — 633-4

Martin M, Daoudal P, Bein C, Bazzi N, Bourscheid D, Floriot C

[Inhaled methadone-induced non cardiogenic pulmonary edema with Acute Respiratory Distress Syndrome].

Presse medicale (Paris, France : 1983) 2011 Apr;40;436-8 — 2011 Apr — 436-8

Karch SB, Stephens BG

Toxicology and pathology of deaths related to methadone: retrospective review.

The Western journal of medicine 2000 Jan;172;11-4 — 2000 Jan — 11-4

Schaaf JT, Spivack ML, Rath GS, Snider GL

Pulmonary edema and adult respiratory distress syndrome following methadone abuse.

The American review of respiratory disease 1973 Jun;107;1047-51 — 1973 Jun — 1047-51

Goldman AL, Enquist RW

Methadone pulmonary edema.

Chest 1973 Feb;63;275-6 — 1973 Feb — 275-6

Cucco RA, Yoo OH, Cregler L, Chang JC

Nonfatal pulmonary edema after "freebase" cocaine smoking.

The American review of respiratory disease 1987 Jul;136;179-81 — 1987 Jul — 179-81

Presant S, Knight L, Klassen G

Methadone-induced pulmonary edema.

Canadian Medical Association journal 1975 Nov 22;113;966-7 — 1975 Nov 22 — 966-7