Philippe Camus, M.D.

Dijon, France

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XII.ak

XII - Cardiovascular involvement / toxicity

Cardiotoxicity

Last update 29/12/2019

The broad term 'cardiotoxicity' encompasses several entities and patterns of cardiac injury including subclinical change in LVEF or cardiac biomarkers, cardiomyopathy, heart failure, AV heart block, conduction abnormalities, myocarditis, myocardial fibrosis, dysrrhythmias, pericarditis, pericardial effusion, tamponade, syncope, cardiac/cardiopulmonary arrest and/or valvular heart dysfunction or disease. Pulmonary edema and pleural effusion may be the annunciating signs and symptoms of cardiotoxicity (PMID 1403060). Cardiotoxicity is a significant hurdle of novel anticancer agent use including the immune checkpoint inhibitors (PMID 25210198, 25574894, 27732808, 29912044, 29980467, 30433897). Can be life-threatening or fatal (PMID 29980467)

Causative drugs

47

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Abiraterone
I.a
I.b
II.b
X.t
XII.a
XII.ak
Anabolic androgenic steroids
I.k
I.o
II.b
II.e
II.h
III.a
IV.ad
VII.e
X.w
XII.a
XII.c
XII.g
XII.h
XII.n
XII.p
XII.x
XII.ak
XIX.n
XIX.z
XIX.ci
Anagrelide
I.a
I.b
VI.a
XI.b
XII.c
XII.g
XII.n
XII.ak
XVI.a
Anthracyclines
II.b
XII.a
XII.g
XII.ak
XII.am
Anti-angiogenesis/-angiogenic agents
V.ae
XI.t
XII.ak
Antimalarial drugs-Antimalarials
XII.a
XII.ak
XIV.a
Arsenic trioxide (As2O3)
I.a
II.a
II.e
II.l
III.a
VI.a
X.t
X.ad
XII.c
XII.ak
Atezolizumab
I.a
I.b
I.l
VI.a
VI.i
VIII.e
X.d
X.f
X.m
X.ag
X.ao
XII.d
XII.ak
XII.bd
XIX.bx
Bevacizumab
I.a
II.e
III.a
III.c
III.g
III.h
III.k
IV.a
V.m
V.s
V.ab
VI.f
VII.a
VII.b
X.f
X.u
XI.t
XII.a
XII.f
XII.g
XII.h
XII.ak
XII.al
XII.av
XIII.f
XVI.ac
XVI.ad
XVI.bh
Bortezomib
I.a
I.b
I.e
I.m
II.e
III.a
VII.b
X.c
X.p
X.q
XII.a
XII.d
XII.g
XII.r
XII.t
XII.ak
XIX.a
XIX.d
XX.e
XX.h
XX.j
Capecitabine
I.n
V.ag
VIII.a
X.m
XI.b
XII.d
XII.h
XII.ah
XII.ak
CAR T-cell therapy
I.ap
II.a
II.c
II.e
II.p
III.c
VI.a
VII.a
X.ap
XII.a
XII.c
XII.g
XII.n
XII.o
XII.q
XII.s
XII.u
XII.ah
XII.aj
XII.ak
XII.bd
XII.bv
XII.bw
XX.b
Carfilzomib
I.a
I.b
III.a
VII.b
X.p
XII.a
XII.g
XII.ak
XX.a
XX.o
XXIII.a
XXIII.b
Chemotherapy, antineoplastic
I.a
I.b
I.c
I.e
I.f
I.g
I.i
I.l
I.m
I.n
I.o
I.w
I.x
I.y
I.z
I.ab
I.ae
I.av
II.a
II.b
II.e
II.f
III.a
IV.a
IV.j
V.a
V.g
VI.a
VI.f
VI.ac
VII.b
VII.c
VII.f
VIII.a
VIII.h
IX.f
IX.j
IX.o
X.c
X.d
X.f
X.i
X.m
X.p
XI.b
XI.l
XI.t
XII.a
XII.b
XII.c
XII.f
XII.g
XII.h
XII.m
XII.n
XII.t
XII.ak
XVI.ac
XVI.ad
XVI.bh
XVI.bp
XVI.by
XVIII.g
XIX.d
XIX.e
XIX.o
XIX.q
XIX.x
XIX.ba
XIX.bd
XIX.bx
XX.b
XX.c
XX.e
XX.g
XX.j
XX.r
XX.ae
XXI.a
XXI.b
XXI.d
Clozapine
I.a
I.c
IV.a
V.a
VI.a
VI.b
VI.m
VII.a
IX.f
X.e
X.q
X.u
X.w
XI.h
XI.l
XI.ah
XII.d
XII.g
XII.i
XII.ak
XIX.bu
XIX.cp
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