The Drug-Induced Respiratory Disease Website and App

Related drugs and/or DIRDs

Pazopanib

Sorafenib

Sunitinib

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Ikeda S, Sekine A, Kato T, Yoshida M, Ogata R, Baba T, Nagahama K, Okudela K, Ogura T

Diffuse alveolar hemorrhage as a fatal adverse effect of bevacizumab: an autopsy case.

Japanese journal of clinical oncology 2014 May;44;497-500 — 2014 May — 497-500

Seto R, Yamada H, Wada H, Osawa M, Nagao T, Nakano Y

Diffuse alveolar haemorrhage may be associated with intravitreal injection of bevacizumab in a patient with systemic risk factors.

BMJ case reports 2011 Feb 02;2011; — 2011 Feb 02