The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Airway (e.g. tracheoesophageal) fistula
Publications
Tracheomediastinal Fistula: Rare Complication of Treatment with Bevacizumab.
Cureus 2018 Apr 03;10;e2419 — 2018 Apr 03 — e2419
Nishie K, Yasuo M, Kitaguchi Y, Kobayashi N, Tateishi K, Ushiki A, Urushihata K, Yamamoto H, Ideura G, Hanaoka M
Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report.
Nagoya journal of medical science 2018 02;80;129-134 — 2018 02 — 129-134