The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.ak

Cardiotoxicity

Publications

Gerasimou C, Vitali GP, Vavougios GD, Papageorgiou C, Douzenis A, Kokoris SI, Liappas I, Rizos E

Clozapine Associated with Autoimmune Reaction, Fever and Low Level Cardiotoxicity - A Case Report.

In vivo (Athens, Greece) 2017 01 02;31;141-143 — 2017 01 02 — 141-143

Rostagno C, Domenichetti S, Gensini GF

Does a subclinical cardiotoxic effect of clozapine exist? Results from a follow-up pilot study.

Cardiovascular & hematological agents in medicinal chemistry 2012 Jun;10;148-53 — 2012 Jun — 148-53