The Drug-Induced Respiratory Disease Website and App

Bortezomib

Pulmonary complications from bortezomib are unusual in the West and have been mainly described in Japan and Asia. The respective role of ethnicity, case definition and other confounding factors cannot be assessed at the present time

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I - Interstitial/parenchymal lung disease

I.a

Pneumonitis (interstitial lung disease/ILD)

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

I.e

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

I.m

Diffuse alveolar damage (DAD) (see alsoo under IIb and XVf)

XLI - Pulmonary edema - Acute lung injury - ARDS

XLI.e

ARDS - Acute lung injury

XLII - Pulmonary/alveolar./airway hemorrhage/bleeding

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

XLVI - Pulmonary vasculopathy

XLVI.b

Pulmonary arterial hypertension

XLIX - Systemic/Distant conditions, syndromes and reactions

XLIX.c

Capillary leak syndrome (CLS)

XLIX.p

Tumor lysis syndrome (TLS)

XLIX.q

Neutrophilic dermatosis (Pyoderma, Sweet syndrome)

LI - Cardiovascular involvement / toxicity

LI.a

Left or biventricular dysfunction/failure

LI.d

Myocarditis (can be fulminant)

LI.g

Cardiomyopathy (acute, subacute, chronic)

LI.r

Pericarditis (see also under XIIc)

LI.t

Heart block (bundle branch- or AV-)

LI.ak

Cardiotoxicity

LVIII - Pathology

LVIII.a

Path: NSIP-cellular pattern (see also Ia, Ib)

LVIII.d

Path: Organizing pneumonia (OP/BOOP) pattern (see also Id)

LIX - Infections & related conditions

LIX.e

Pneumocystis jiroveci pneumonia

LIX.h

Nontuberculous pulmonary mycobacterial infection/superinfection

LIX.j

Mucormycosis (pulmonary, tracheobronchial or systemic)