The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Can be refractory to corticosteroids (PMID 30837232)

Publications

Li R, Lee G, El-Sherief A

Immunotherapy causing pneumonitis in a patient with non-small cell lung cancer (NSCLC).

BMJ case reports 2019 Mar 04;12; — 2019 Mar 04

Shannon VR

Pneumotoxicity associated with immune checkpoint inhibitor therapies.

Current opinion in pulmonary medicine 2017 07;23;305-316 — 2017 07 — 305-316

Tabchi S, Messier C, Blais N

Immune-mediated respiratory adverse events of checkpoint inhibitors.

Current opinion in oncology 2016 07;28;269-77 — 2016 07 — 269-77